High level sill and dyke intrusions initiated from rapidly buried mafic lava flows in scoria cones of Tongoa, Vanuatu (New Hebrides), South Pacific

Scoria cones are generally considered to grow rapidly in days to weeks or months. During their growth lava flows may be fed onto the cone surface from lava-lake breaches, or form by coalescence of spatter; such flows are preserved interbedded with scoria lapilli and ash beds. On Tongoa, an island of the Vanuatu volcanic arc in the South Pacific, a series of scoria cones developed during the Holocene, forming a widespread monogenetic volcanic field. Half sections of scoria cones along the coast expose complex interior architecture cone architectures. On the western side of Tongoa Island a scoria cone remnant with steeply crater-ward dipping beds of scoria ash and lapilli contains various dm-to-m thick lava flows, which are connected by irregular dikes cutting obliquely across the beds of the cone. The lava flows are coherent igneous bodies with well-developed flow top and basal breccias. The lavas interbedded with the cone-forming layers are part of a larger (up to 7 m thick) body that is connected to dykes and sills of irregular geometries that intrude the cone's pyroclastic layers. This 3D relationship suggests that the lava flows were buried quickly under the accumulating scoriaceous deposits. This allowed subsequent escape of magma from the fluid interiors of flows, with the magma then squeezed upward or laterally into the accumulating pyroclastic pile. Movement of the pile above the partly mobile lava, and potential destabilisation during intrusion into the pile of lava squeezed from the flows, may signal the onset of localised cone failures, and could be implicated in development of major cone breaches (e.g. Paricutin)

Compositional variation during monogenetic volcano growth and its implications for magma supply to continental volcanic fields

Individual volcanoes of continental monogenetic volcanic fields are generally presumed to erupt single magma batches during brief eruptions. Nevertheless, in two unrelated volcanic fields (the Waipiata volcanic field, New Zealand, and the Miocene-Pliocene volcanic field in western Hungary), we have identified pronounced and systematic compositional differences among products of individual volcanoes. We infer that this indicates a two-stage process of magma supply for these volcanoes. Each volcano records: (1) intrusion of a basanitic parent magma to lower- to mid-crustal levels and its subsequent fractionation to form a tephritic residual melt;, (2) subsequent transection of this reservoir by a second batch of basanitic melt, with tephrite rising to the surface at the head of the propagating basanite dyke. Eruption at the surface then yields initial tephrite, typically erupted as pyroclasts, followed by eruption and shallow intrusion of basanite from deeper in the dyke. By analogy with similar tephrite-basanite eruptions along rift zones of intraplate ocean-island volcanoes, we infer that fractionation to tephrite would have required decades to centuries. We conclude that the two studied continental monogenetic volcanic fields demonstrate a consistent history of early magmatic injections that fail to reach the surface, followed by capture and partial eruption of their evolved residues in the course of separate and significantly later injections of basanite that extend to the surface and erupt. This systematic behaviour probably reflects the difficulty of bringing small volumes of dense, primitive magma to the surface from mantle source regions. Ascent through continental crust is aided by the presence in the dyke head of buoyant tephrite captured during transection of the earlier-emplaced melt bodies

On the off-axis tensile test for unidirectional composites

The off axis tensile test was examined experimentally to obtain actual displacement fields over the surface of graphite polyimide coupon specimens. The experimental results were compared with approximate analytical solutions and generated finite element results. An optical method of high sensitivity moire interferometry was used to determine the actual displacements to high precision. The approximate analytical solution and the finite element results compare very favorably with the measured centerline displacements in the test section, and the finite element displacement fields provide excellent agreement with the moire displacements throughout the specimen. A 15 degree fiber orientation and coupon aspect ratios of 5 and 15 are presented

Bone Marrow Stromal Cells Use Tgf-Β to Suppress Allergic Responses in a Mouse Model of Ragweed-Induced Asthma

Bone marrow stromal cells [BMSCs; also known as mesenchymal stem cells (MSCs)] effectively suppress inflammatory responses in acute graft-versus-host disease in humans and in a number of disease models in mice. Many of the studies concluded that BMSC- driven immunomodulation is mediated by the suppression of pro- inflammatory Th1 responses while rebalancing the Th1/Th2 ratio toward Th2. In this study, using a ragweed induced mouse asthma model, we studied if BMSCs could be beneficial in an allergic, Th2- dominant environment. When BMSCs were injected i.v. at the time of the antigen challenge, they protected the animals from the majority of asthma-specific pathological changes, including inhib- ition of eosinophil infiltration and excess mucus production in the lung, decreased levels of Th2 cytokines (IL-4, IL-5, and IL-13) in bronchial lavage, and lowered serum levels of Th2 immunoglobu- lins (IgG1 and IgE). To explore the mechanism of the effect we used BMSCs isolated from a variety of knockout mice, performed in vivo blocking of cytokines and studied the effect of asthmatic serum and bronchoalveolar lavage from ragweed challenged animals on the BMSCs in vitro. Our results suggest that IL-4 and/ or IL-13 activate the STAT6 pathway in the BMSCs resulting in an increase of their TGF-β production, which seems to mediate the beneficial effect, either alone, or together with regulatory T cells, some of which might be recruited by the BMSCs. These data sug- gest that, in addition to focusing on graft-versus-host disease and autoimmune diseases, allergic conditions—specifically therapy resistant asthma—might also be a likely target of the recently discovered cellular therapy approach using BMSCs

Experiment K-6-21. Effect of microgravity on 1) metabolic enzymes of type 1 and type 2 muscle fibers and on 2) metabolic enzymes, neutransmitter amino acids, and neurotransmitter associated enzymes in motor and somatosensory cerebral cortex. Part 1: Metabolic enzymes of individual muscle fibers; part 2: metabolic enzymes of hippocampus and spinal cord

The individual fibers of any individual muscle vary greatly in enzyme composition, a fact which is obscured when enzyme levels of a whole muscle are measured. The purpose of this study was therefore to assess the changes due to weightless on the enzyme patterns composed by the individual fibers within the flight muscles. In spite of the limitation in numbers of muscles examined, it is apparent that: (1) that the size of individual fibers (i.e., their dry weight) was reduced about a third, (2) that this loss in dry mass was accompanied by changes in the eight enzymes studied, and (3) that these changes were different for the two muscles, and different for the two enzyme groups. In the soleus muscle the absolute amounts of the three enzymes of oxidative metabolism decreased about in proportion to the dry weight loss, so that their concentration in the atrophic fibers was almost unchanged. In contrast, there was little loss among the four enzymes of glycogenolysis - glycolysis so that their concentrations were substantially increased in the atrophic fibers. In the TA muscle, these seven enzymes were affected in just the opposite direction. There appeared to be no absolute loss among the oxidative enzymes, whereas the glycogenolytic enzymes were reduced by nearly half, so that the concentrations of the first metabolic group were increased within the atrophic fibers and the concentrations of the second group were only marginally decreased. The behavior of hexokinase was exceptional in that it did not decrease in absolute terms in either type of muscle and probably increased as much as 50 percent in soleus. Thus, their was a large increase in concentration of this enzyme in the atrophied fibers of both muscles. Another clear-cut finding was the large increase in the range of activities of the glycolytic enzymes among individual fibers of TA muscles. This was due to the emergence of TA fibers with activities for enzymes of this group extending down to levels as low as those found in control soleus muscles. It would be interesting to know if this represents a transition stage, and whether with prolonged weightlessness most of the fibers would be transformed into a low glycogenolytic type

Orbital Magnetism and Current Distribution of Two-Dimensional Electrons under Confining Potential

The spatial distribution of electric current under magnetic field and the resultant orbital magnetism have been studied for two-dimensional electrons under a harmonic confining potential V(\vecvar{r})=m \omega_0^2 r^2/2 in various regimes of temperature and magnetic field, and the microscopic conditions for the validity of Landau diamagnetism are clarified. Under a weak magnetic field (\omega_c\lsim\omega_0, \omega_c being a cyclotron frequency) and at low temperature (T\lsim\hbar\omega_0), where the orbital magnetic moment fluctuates as a function of the field, the currents are irregularly distributed paramagnetically or diamagnetically inside the bulk region. As the temperature is raised under such a weak field, however, the currents in the bulk region are immediately reduced and finally there only remains the diamagnetic current flowing along the edge. At the same time, the usual Landau diamagnetism results for the total magnetic moment. The origin of this dramatic temperature dependence is seen to be in the multiple reflection of electron waves by the boundary confining potential, which becomes important once the coherence length of electrons gets longer than the system length. Under a stronger field (\omega_c\gsim\omega_0), on the other hand, the currents in the bulk region cause de Haas-van Alphen effect at low temperature as T\lsim\hbar\omega_c. As the temperature gets higher (T\gsim\hbar\omega_c) under such a strong field, the bulk currents are reduced and the Landau diamagnetism by the edge current is recovered.Comment: 15 pages, 11 figure

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation:relevance to autosomal dominant hypocalcemia type 1 (ADH1)

Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum parathyroid hormone (PTH) concentrations and hypercalciuria. Negative allosteric CaSR modulators, known as calcilytics, have been shown to normalise the gain-of-function associated with ADH-causing CaSR mutations in vitro and represent a potential targeted therapy for ADH1. However, the effectiveness of calcilytic drugs for the treatment of ADH1-associated hypocalcemia remains to be established. We have investigated NPS 2143, a calcilytic compound, for the treatment of ADH1 by in vitro and in vivo studies involving a mouse model, known as Nuf, which harbors a gain-of-function CaSR mutation, Leu723Gln. Wild-type (Leu723) and Nuf mutant (Gln723) CaSRs were expressed in HEK293 cells and the effect of NPS 2143 on their intracellular calcium responses determined by flow cytometry. NPS 2143 was also administered as a single intraperitoneal bolus to wild-type and Nuf mice and plasma concentrations of calcium and PTH, and urinary calcium excretion measured. In vitro administration of NPS 2143 decreased the intracellular calcium responses of HEK293 cells expressing the mutant Gln723 CaSR in a dose-dependent manner, thereby rectifying the gain-of-function associated with the Nuf mouse CaSR mutation. Intraperitoneal injection of NPS 2143 in Nuf mice led to significant increases in plasma calcium and PTH without elevating urinary calcium excretion. These studies of a mouse model with an activating CaSR mutation demonstrate NPS 2143 to normalize the gain-of-function causing ADH1, and improve the hypocalcemia associated with this disorder

The buckling response of symmetrically laminated composite plates having a trapezoidal planform area

The focus of this work is the buckling response of symmetrically laminated composite plates having a planform area in the shape of an isosceles trapezoid. The loading is assumed to be inplane and applied perpendicular to the parallel ends of the plate. The tapered edges of the plate are assumed to have simply supported boundary conditions, while the parallel ends are assumed to have either simply supported or clamped boundary conditions. A semi-analytic closed-form solution based on energy principles and the Trefftz stability criterion is derived and solutions are obtained using the Rayleigh-Ritz method. Intrinsic in this solution is a simplified prebuckling analysis which approximates the inplane force resultant distributions by the forms Nx=P/W(x) and Ny=Nxy=0, where P is the applied load and W(x) is the plate width which, for the trapezoidal planform, varies linearly with the lengthwise coordinate x. The out-of-plane displacement is approximated by a double trigonometric series. This analysis is posed in terms of four nondimensional parameters representing orthotropic and anisotropic material properties, and two nondimensional parameters representing geometric properties. For comparison purposes, a number of specific plate geometry, ply orientation, and stacking sequence combinations are investigated using the general purpose finite element code ABAQUS. Comparison of buckling coefficients calculated using the semi-analytical model and the finite element model show agreement within 5 percent, in general, and within 15 percent for the worst cases. In order to verify both the finite element and semi-analytical analyses, buckling loads are measured for graphite/epoxy plates having a wide range of plate geometries and stacking sequences. Test fixtures, instrumentation system, and experimental technique are described. Experimental results for the buckling load, the buckled mode shape, and the prebuckling plate stiffness are presented and show good agreement with the analytical results regarding the buckling load and the prebuckling plate stiffness. However, the experimental results show that for some cases the analysis underpredicts the number of halfwaves in the buckled mode shape. In the context of the definitions of taper ratio and aspect ratio used in this study, it is concluded that the buckling load always increases as taper ratio increases for a given aspect ratio for plates having simply supported boundary conditions on the parallel ends. There are combinations of plate geometry and ply stackling sequences, however, that reverse this trend for plates having clamped boundary conditions on the parallel ends such that an increase in the taper ratio causes a decrease in the buckling load. The clamped boundary conditions on the parallel ends of the plate are shown to increase the buckling load compared to simply supported boundary conditions. Also, anisotropy (the D16 and D26 terms) is shown to decrease the buckling load and skew the buckled mode shape for both the simply supported and clamped boundary conditions

A new sdO+dM binary with extreme eclipses and reflection effect

We report the discovery of a new totally-eclipsing binary (RA=06:40:29.11; Dec=+38:56:52.2; J=2000.0; Rmax=17.2 mag) with an sdO primary and a strongly irradiated red dwarf companion. It has an orbital period of Porb=0.187284394(11) d and an optical eclipse depth in excess of 5 magnitudes. We obtained two low-resolution classification spectra with GTC/OSIRIS and ten medium-resolution spectra with WHT/ISIS to constrain the properties of the binary members. The spectra are dominated by H Balmer and He II absorption lines from the sdO star, and phase-dependent emission lines from the irradiated companion. A combined spectroscopic and light curve analysis implies a hot subdwarf temperature of Teff(spec) = 55 000 +/- 3000K, surface gravity of log g(phot) = 6.2 +/- 0.04 (cgs) and a He abundance of log(nHe/nH) = -2.24 +/- 0.40. The hot sdO star irradiates the red-dwarf companion, heating its substellar point to about 22 500K. Surface parameters for the companion are difficult to constrain from the currently available data: the most remarkable features are the strong H Balmer and C II-III lines in emission. Radial velocity estimates are consistent with the sdO+dM classification. The photometric data do not show any indication of sdO pulsations with amplitudes greater than 7mmag, and Halpha-filter images do not provide evidence of the presence of a planetary nebula associated with the sdO star.Comment: 13 pages, 5 figures; accepted for publication in Ap